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Cyclosporine for corticosteroid-refractory acute generalized exanthematous pustulosis due to hydroxychloroquine.

Authors
  • Castner, Nicholas Bradford1
  • Harris, Jessica Crabbe2
  • Motaparthi, Kiran2
  • 1 Department of Dermatology, University of South Florida Morsani College of Medicine, Tampa, Florida.
  • 2 Department of Dermatology, University of Florida College of Medicine, Gainesville, Florida.
Type
Published Article
Journal
Dermatologic Therapy
Publisher
Wiley (Blackwell Publishing)
Publication Date
Sep 01, 2018
Volume
31
Issue
5
Identifiers
DOI: 10.1111/dth.12660
PMID: 30152569
Source
Medline
Keywords
Language
English
License
Unknown

Abstract

Acute generalized exanthematous pustulosis most often manifests 1-2 days following exposure to a characteristic drug, such as aminopenicillins, calcium-channel blockers, or terbinafine. Recovery is usually rapid following drug withdrawal, and systemic corticosteroids represent the historic treatment of choice. Herein, acute generalized exanthematous pustulosis incited by hydroxychloroquine is briefly reviewed: a prolonged latency and recalcitrance to corticosteroids are noteworthy. In this unique context, cyclosporine tapered over several months is an effective therapeutic option. © 2018 Wiley Periodicals, Inc.

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