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Cyclosporin A--a chemoprotectant against microcystin-LR toxicity.

Authors
  • Hermansky, S J1
  • Casey, P J
  • Stohs, S J
  • 1 Creighton University Health Sciences Center, Omaha, NE 68178.
Type
Published Article
Journal
Toxicology Letters
Publisher
Elsevier
Publication Date
Dec 01, 1990
Volume
54
Issue
2-3
Pages
279–285
Identifiers
PMID: 2260124
Source
Medline
License
Unknown

Abstract

Microcystin-LR (MCLR) is a potent hepatotoxin that rapidly produces death in experimental animals. We have shown that cyclosporin A (CsA) can prevent the toxic and lethal effects of MCLR in mice. The LD50 of MCLR in mice is approximately 61 micrograms/kg, and 100 micrograms/kg produces death in 100% of treated mice. The minimum dose of CsA which prevented lethality in mice given 100 micrograms MCLR/kg i.p. was 10 mg/kg. This dose of CsA did not protect mice against higher doses of MCLR. Survival of all mice given 100 micrograms MCLR/kg was achieved if 10 mg CsA/kg was given 0.5-3 h prior to the MCLR but not if the CsA was co-administered or given after the MCLR. The results indicate that CsA effectively protects mice against a lethal dose of MCLR, but that the time of administration and the dose of CsA are critical determinants of the chemoprotective effects.

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