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Cyclometalated Benzimidazole Osmium(II) Complexes with Antiproliferative Activity in Cancer Cells Disrupt Calcium Homeostasis

Authors
  • Hernández-García, Alba
  • Marková, Lenka
  • Santana, María Dolores
  • Prachařová, Jitka
  • Bautista, Delia
  • Kostrhunová, Hana
  • Novohradský, Vojtěch
  • Brabec, Viktor
  • Ruiz, José
  • Kašpárková, Jana
Type
Published Article
Journal
Inorganic Chemistry
Publisher
American Chemical Society
Publication Date
Apr 11, 2023
Volume
62
Issue
16
Pages
6474–6487
Identifiers
DOI: 10.1021/acs.inorgchem.3c00501
PMID: 37040203
PMCID: PMC10131226
Source
PubMed Central
Disciplines
  • Article
License
Unknown

Abstract

New panchromatic osmium(II) complexes showing high photostability and exhibiting markedly higher antiproliferative activity in the 2D monolayer cancer cell lines and 3D multicellular tumor spheroids than conventional cisplatin; investigated osmium(II) complexes activating the ER stress pathway in cancer cells and disrupting calcium homeostasis; largely unexplored potential of osmium-based complexes for cancer chemotherapy; and hints about the mechanism and targets of systemic osmium toxicity.

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