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Cyclic adenosine monophosphate: function in photoreceptors.

Authors
  • Miller, W H
  • Gorman, R E
  • Bitensky, M W
Type
Published Article
Journal
Science (New York, N.Y.)
Publication Date
Oct 15, 1971
Volume
174
Issue
4006
Pages
295–297
Identifiers
PMID: 4330304
Source
Medline
License
Unknown

Abstract

Inactivation of adenylate cyclase in outer segments of retinal photoreceptor cells is proportional to the bleaching of rhodopsin. Membranes of the outer segments also contain a particulate, light-insensitive phosphodiesterase of high specific activity. In electrophysiological experiments, application of cyclic adenosine monophosphate along with a methylxanthine mimics the effects of illumination on the photoreceptor cell of the compound eye of Limulus.

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