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Cyclic adenosine 3',5'-monophosphate in Escherichia coli.

Authors
  • Buettner, M J
  • Spitz, E
  • Rickenberg, H V
Type
Published Article
Journal
Journal of bacteriology
Publication Date
Jun 01, 1973
Volume
114
Issue
3
Pages
1068–1073
Identifiers
PMID: 4351386
Source
Medline
License
Unknown

Abstract

The concentration of cyclic adenosine 3',5'-monophosphate (c-AMP) in Escherichia coli growing on different sources of carbon was studied. Cultures utilizing a source of carbon that supported growth relatively poorly had consistently higher concentrations of c-AMP than did cultures utilizing sugars that supported rapid growth. This relationship was also observed in strains defective in c-AMP phosphodiesterase and simultaneously resistant to catabolite repression; in such strains the c-AMP concentration was slightly higher for several sources of carbon tested. Cultures continued to synthesize c-AMP and secreted it into the medium, under conditions that brought about an inhibition of the intracellular accumulation of the cyclic nucleotide. Transient repression of the synthesis of beta-galactosidase was not associated with an abrupt decrease in the cellular concentration of c-AMP.

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