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Cutaneous vaccination using microneedles coated with hepatitis C DNA vaccine.

Authors
  • Gill, H S
  • Söderholm, J
  • Prausnitz, M R
  • Sällberg, M
Type
Published Article
Journal
Gene Therapy
Publisher
Springer Nature
Publication Date
Jun 01, 2010
Volume
17
Issue
6
Pages
811–814
Identifiers
DOI: 10.1038/gt.2010.22
PMID: 20200562
Source
Medline
License
Unknown

Abstract

The skin is potentially an excellent organ for vaccine delivery because of accessibility and the presence of immune cells. However, no simple and inexpensive cutaneous vaccination method is available. Micron-scale needles coated with DNA were tested as a simple, inexpensive device for skin delivery. Vaccination with a plasmid encoding hepatitis C virus nonstructural 3/4A protein using microneedles effectively primed specific cytotoxic T lymphocytes (CTLs). Importantly, the minimally invasive microneedles were as efficient in priming CTLs as more complicated or invasive delivery techniques, such as gene gun and hypodermic needles. Thus, microneedles may offer a promising technology for DNA vaccination.

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