Affordable Access

deepdyve-link
Publisher Website

Cutaneous nerve fibers participate in the progression of psoriasis by linking epidermal keratinocytes and immunocytes.

Authors
  • Chen, Si-Qi1
  • Chen, Xue-Yan1
  • Cui, Ying-Zhe1
  • Yan, Bing-Xi1
  • Zhou, Yuan1
  • Wang, Zhao-Yuan1
  • Xu, Fan1
  • Huang, Yan-Zhou1
  • Zheng, Yu-Xin1
  • Man, Xiao-Yong2
  • 1 Department of Dermatology, Second Affiliated Hospital, Zhejiang University School of Medicine, #88 Jiefang Road, Hangzhou, China. , (China)
  • 2 Department of Dermatology, Second Affiliated Hospital, Zhejiang University School of Medicine, #88 Jiefang Road, Hangzhou, China. [email protected] , (China)
Type
Published Article
Journal
Cellular and Molecular Life Sciences
Publisher
Springer-Verlag
Publication Date
Apr 30, 2022
Volume
79
Issue
5
Pages
267–267
Identifiers
DOI: 10.1007/s00018-022-04299-x
PMID: 35488965
Source
Medline
Keywords
Language
English
License
Unknown

Abstract

Recent studies have illustrated that psoriatic lesions are innervated by dense sensory nerve fibers. Psoriatic plaques appeared to improve after central or peripheral nerve injury. Therefore, the nervous system may play a vital role in psoriasis. We aimed to clarify the expression of nerve fibers in psoriasis and their relationship with immune cells and keratinocytes, and to explore the effect of skin nerve impairment. Our results illustrated that nerve fibers in psoriatic lesions increased and were closely innervated around immune cells and keratinocytes. RNA-seq analysis showed that peripheral sensory nerve-related genes were disrupted in psoriasis. In spinal cord hemi-section mice, sensory impairment improved psoriasiform dermatitis and inhibited the abnormal proliferation of keratinocytes. Botulinum toxin A alleviated psoriasiform dermatitis by inhibiting the secretion of calcitonin gene-related peptide. Collectively, cutaneous nerve fibers participate in the progression of psoriasis by linking epidermal keratinocytes and immunocytes. Neurological intervention may be a new treatment strategy for psoriasis. © 2022. The Author(s), under exclusive licence to Springer Nature Switzerland AG.

Report this publication

Statistics

Seen <100 times