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Current treatment for colorectal liver metastases.

Authors
  • Misiakos, Evangelos P
  • Karidis, Nikolaos P
  • Kouraklis, Gregory
Type
Published Article
Journal
World Journal of Gastroenterology
Publisher
Baishideng Publishing Group Co
Publication Date
Sep 28, 2011
Volume
17
Issue
36
Pages
4067–4075
Identifiers
DOI: 10.3748/wjg.v17.i36.4067
PMID: 22039320
Source
Medline
Keywords
License
Unknown

Abstract

Surgical resection offers the best opportunity for survival in patients with colorectal cancer metastatic to the liver, with five-year survival rates up to 58% in selected cases. However, only a minority are resectable at the time of diagnosis. Continuous research in this field aims at increasing the percentage of patients eligible for resection, refining the indications and contraindications for surgery, and improving overall survival. The use of surgical innovations, such as staged resection, portal vein embolization, and repeat resection has allowed higher resection rates in patients with bilobar disease. The use of neoadjuvant chemotherapy allows up to 38% of patients previously considered unresectable to be significantly downstaged and eligible for hepatic resection. Ablative techniques have gained wide acceptance as an adjunct to surgical resection and in the management of patients who are not surgical candidates. Current management of colorectal liver metastases requires a multidisciplinary approach, which should be individualized in each case.

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