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Current status of long non-coding RNAs in human cancer with specific focus on colorectal cancer.

Authors
Type
Published Article
Journal
International Journal of Molecular Sciences
1422-0067
Publisher
MDPI AG
Publication Date
Volume
15
Issue
8
Pages
13993–14013
Identifiers
DOI: 10.3390/ijms150813993
PMID: 25119862
Source
Medline

Abstract

The latest investigations of long non-coding RNAs (lncRNAs) have revealed their important role in human cancers. LncRNAs are larger than 200 nucleotides in length and fulfill their cellular purpose without being translated into proteins. Though the molecular functions of some lncRNAs have been elucidated, there is still a high number of lncRNAs with unknown or controversial functions. In this review, we provide an overview of different lncRNAs and their role in human cancers. In particular, we emphasize their importance in tumorigenesis of colorectal cancer, the third most common cancer worldwide.

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