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[Current situation of researches on the molecule mechanism of hormone refractory prostate cancer].

Authors
  • Yang, Nian-qin
  • Wang, Yi-xin
Type
Published Article
Journal
Zhonghua nan ke xue = National journal of andrology
Publication Date
Jun 01, 2006
Volume
12
Issue
6
Pages
551–554
Identifiers
PMID: 16833202
Source
Medline
License
Unknown

Abstract

Most cases of prostate cancer become hormone refractory after 12 to 18 months of androgen deprivation therapy. The etiology of the disease is thought to be multifactorial, associated with genetic, dietary, and environmental factors. The article reviews the current situation of researches at home and abroad on the molecule mechanism of hormone refractory. It expounds the influence of the androgen receptor and its genetic mutation, apoptosis and the gene changes of p53, p21, EphB2 on prostate cancer. It is hoped to be of some directive value for the studies of prostate cancer.

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