Lectins are diverse group of carbohydrate binding proteins distributed ubiquitously in plant species. Lectins are the subject of intense investigation. Therefore, in the past few years studies on legume lectins with respect to their biochemical and pharmacological properties have been extensively carried out. Legume lectins are reported to contain antifungal, mitogenic, immunomodulatory, and antitumor properties. Some of the lectin also display anti-HIV-1 reverse transcriptase and antineoplastic activities. Plant lectins are expected to open new vistas for the design and development of drugs to be used against different serious diseases. This article aims to review up-to-date advances of legume lectins vis-à-vis structure, biological properties, and their practical applications.