Affordable Access

deepdyve-link
Publisher Website

Current review of in vivo GBM rodent models: emphasis on the CNS-1 tumour model.

Authors
  • Jacobs, Valerie L
  • Valdes, Pablo A
  • Hickey, William F
  • De Leo, Joyce A
Type
Published Article
Journal
ASN neuro
Publication Date
Jan 01, 2011
Volume
3
Issue
3
Identifiers
DOI: 10.1042/AN20110014
PMID: 21740400
Source
Medline
License
Unknown

Abstract

GBM (glioblastoma multiforme) is a highly aggressive brain tumour with very poor prognosis despite multi-modalities of treatment. Furthermore, recent failure of targeted therapy for these tumours highlights the need of appropriate rodent models for preclinical studies. In this review, we highlight the most commonly used rodent models (U251, U86, GL261, C6, 9L and CNS-1) with a focus on the pathological and genetic similarities to the human disease. We end with a comprehensive review of the CNS-1 rodent model.

Report this publication

Statistics

Seen <100 times