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Current and Perspective Diagnostic Techniques for COVID-19

Authors
  • Yuan, Xi1
  • Yang, Chengming2
  • He, Qian1
  • Chen, Junhu3
  • Yu, Dongmei1, 4
  • Li, Jie1, 5
  • Zhai, Shiyao1
  • Qin, Zhifeng6
  • Du, Ke7
  • Chu, Zhenhai2
  • Qin, Peiwu1
  • 1 Tsinghua-Berkeley Shenzhen Institute, China , (China)
  • 2 Southern University of Science and Technology Hospital, China , (China)
  • 3 Chinese Center for Disease Control and Prevention, China , (China)
  • 4 Southern University of Science and Technology, China , (China)
  • 5 Kunming Dog Base of Police Security, Ministry of Public Security, China , (China)
  • 6 Shenzhen Customs District People’s Republic of China, China , (China)
  • 7 Rochester Institute of Technology, United States , (United States)
Type
Published Article
Journal
ACS Infectious Diseases
Publisher
American Chemical Society
Publication Date
Jul 17, 2020
Volume
6
Issue
8
Pages
1998–2016
Identifiers
DOI: 10.1021/acsinfecdis.0c00365
PMID: 32677821
PMCID: PMC7409380
Source
PubMed Central
Keywords
License
Green

Abstract

Since late December 2019, the coronavirus pandemic (COVID-19; previously known as 2019-nCoV) caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has been surging rapidly around the world. With more than 1,700,000 confirmed cases, the world faces an unprecedented economic, social, and health impact. The early, rapid, sensitive, and accurate diagnosis of viral infection provides rapid responses for public health surveillance, prevention, and control of contagious diffusion. More than 30% of the confirmed cases are asymptomatic, and the high false-negative rate (FNR) of a single assay requires the development of novel diagnostic techniques, combinative approaches, sampling from different locations, and consecutive detection. The recurrence of discharged patients indicates the need for long-term monitoring and tracking. Diagnostic and therapeutic methods are evolving with a deeper understanding of virus pathology and the potential for relapse. In this Review, a comprehensive summary and comparison of different SARS-CoV-2 diagnostic methods are provided for researchers and clinicians to develop appropriate strategies for the timely and effective detection of SARS-CoV-2. The survey of current biosensors and diagnostic devices for viral nucleic acids, proteins, and particles and chest tomography will provide insight into the development of novel perspective techniques for the diagnosis of COVID-19.

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