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Current Insights in Cutaneous Lupus Erythematosus Immunopathogenesis

Authors
  • Garelli, Colton J.
  • Ahmed Refat, Maggi
  • Nanaware, Padma P.
  • Ramirez-Ortiz, Zaida G.
  • Rashighi, Medhi
  • Richmond, Jillian M.
Publication Date
Jul 02, 2020
Source
[email protected]
Keywords
License
Green
External links

Abstract

Cutaneous Lupus Erythematosus (CLE) is a clinically diverse group of autoimmune skin diseases with shared histological features of interface dermatitis and autoantibodies deposited at the dermal-epidermal junction. Various genetic and environmental triggers of CLE promote infiltration of T cells, B cells, neutrophils, antigen presenting cells, and NK cells into lesional skin. In this mini-review, we will discuss the clinical features of CLE, insights into CLE immunopathogenesis, and novel treatment approaches.

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