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Current developments in the discovery and design of new drug candidates from plant natural product leads.

Authors
Type
Published Article
Journal
Journal of natural products
Publication Date
Volume
67
Issue
2
Pages
273–283
Identifiers
PMID: 14987069
Source
Medline
License
Unknown

Abstract

This review article will emphasize recent research in the Natural Products Laboratory, School of Pharmacy, University of North Carolina at Chapel Hill, on various classes of plant-derived compounds that possess potent antitumor or anti-HIV activity. These compounds were obtained by bioactivity- and mechanism of action-directed isolation and characterization coupled with rational drug design-based modification and analogue synthesis. Structural modification, SAR, and mechanism of action studies are discussed.

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