Affordable Access

[Current data on granulocytes donations].

Authors
  • de Talancé, D Lemau
  • Benomar, D
  • Boulat, C
  • Beaumont, J-L
Type
Published Article
Journal
Transfusion Clinique et Biologique
Publisher
Elsevier
Publication Date
Apr 01, 2004
Volume
11
Issue
2
Pages
106–112
Identifiers
PMID: 15120109
Source
Medline
License
Unknown

Abstract

Granulocyte transfusion is uncommon but essential for some aplastic patients with major infection and those with septic granulomatosis disease and visceral aspergillosis. Compatibility between donor and recipient (ABO, D, Kell blood type, cytomegalovirus) is necessary. Stimulation by dexamethasone, before use of GCSF, permits to obtain approximately 10 x 10(9) white cells per l. Doses of heparin must be calculated to ensure an efficient hypocoagulation without any trouble for the donor immediately after his donation. Sedimentation by hydroxyethylstarch is an unavoidable element to obtain the most efficient separation of granulocytes. Most donations present an amount of white cells between 2 and 4 10 x 10(10). This enables to transfuse efficiently children and adults.

Report this publication

Statistics

Seen <100 times