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Current concepts and unmet needs in psoriatic arthritis.

Authors
  • Mahmood, Farrouq1
  • Coates, Laura C2
  • Helliwell, Philip S3
  • 1 Clinical Research Fellow in Rheumatology, Bradford Teaching Hospitals NHS Foundation Trust, Bradford, UK.
  • 2 Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, University of Oxford, Oxford, UK.
  • 3 Leeds Institute of Rheumatic & Musculoskeletal Medicine, University of Leeds, Chapel Allerton Hospital, Chapeltown Road, Leeds, LS7 4SA, UK. [email protected]
Type
Published Article
Journal
Clinical Rheumatology
Publisher
Springer-Verlag
Publication Date
Feb 01, 2018
Volume
37
Issue
2
Pages
297–305
Identifiers
DOI: 10.1007/s10067-017-3908-y
PMID: 29134513
Source
Medline
Keywords
License
Unknown

Abstract

Psoriatic arthritis is a chronic inflammatory arthritis that is part of the spondyloarthropathy group of rheumatic diseases and has associated co-morbidities. It can present with various clinical manifestations making diagnosis and treatment challenging, resulting in significant disability and reduced quality of life for patients. Whilst there have been advances in understanding the pathogenic mechanisms of the disease which have resulted in targeted therapies, there is still the need for further studies as some patients fail or are intolerant of current therapies. Better identification of early disease and knowledge of prognostic markers would enable clinicians to initiate appropriate therapy with the expectation that early aggressive treatment will minimise joint damage progression. Improved knowledge of the condition would also enable clinicians to better tailor specific treatment strategies for each of the various clinical domains in psoriatic arthritis.

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