Current Biomedical Use of Copper Chelation Therapy

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Current Biomedical Use of Copper Chelation Therapy

Authors
  • Baldari, Silvia
  • Di Rocco, Giuliana
  • Toietta, Gabriele
Type
Published Article
Journal
International Journal of Molecular Sciences
Publisher
MDPI AG
Publication Date
Feb 17, 2020
Volume
21
Issue
3
Identifiers
DOI: 10.3390/ijms21031069
PMID: 32041110
Source
MyScienceWork
Keywords
License
Green

Abstract

Copper is an essential microelement that plays an important role in a wide variety of biological processes. Copper concentration has to be finely regulated, as any imbalance in its homeostasis can induce abnormalities. In particular, excess copper plays an important role in the etiopathogenesis of the genetic disease Wilson's syndrome, in neurological and neurodegenerative pathologies such as Alzheimer's and Parkinson's diseases, in idiopathic pulmonary fibrosis, in diabetes, and in several forms of cancer. Copper chelating agents are among the most promising tools to keep copper concentration at physiological levels. In this review, we focus on the most relevant compounds experimentally and clinically evaluated for their ability to counteract copper homeostasis deregulation. In particular, we provide a general overview of the main disorders characterized by a pathological increase in copper levels, summarizing the principal copper chelating therapies adopted in clinical trials.

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