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Curious Residents of the Thyroid Gland: Two Case Reports of Colorectal Carcinoma Metastasis by Fine-Needle Aspiration Diagnosis

Authors
  • Melis, Céline
  • Ballaux, Florence
  • Bourgain, Claire
Type
Published Article
Journal
Acta Cytologica
Publisher
S. Karger AG
Publication Date
Jul 13, 2018
Volume
62
Issue
5-6
Pages
443–449
Identifiers
DOI: 10.1159/000490367
PMID: 30007959
Source
Karger
Keywords
License
Green
External links

Abstract

Background: The most frequent metastases to the thyroid originate in the kidney, lung or breast. Colorectal adenocarcinoma represents less than 4% of metastases to the thyroid gland. Solitary metastases of colorectal cancer with no other manifestation of disseminated cancer disease are exceedingly rare. Within the Bethesda Classification for Reporting ­Thyroid Cytopathology, metastases are included in Diagnostic Categories “Suspicious for Malignancy” and “Malignant.” Cases: We present 2 cases of colorectal adenocarcinoma metastatic to the thyroid gland, diagnosed by fine-needle aspiration (FNA). One metastasis occurred in normal thyroid parenchyma; the other was a tumour-to-tumour metastasis into a follicular carcinoma of the thyroid. The latter is the first published tumour-to-tumour metastasis of a colorectal carcinoma in the thyroid from which both components were diagnosed by FNA. Conclusion: Diagnosing a metastasis to the thyroid is challenging. On FNA, a dual cell population should raise suspicion. Immunocytochemical and molecular analysis may be helpful. Clinical information is essential in guiding specific ancillary technique panels in scant cellular material.

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