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Curcumin and inflammation in non-alcoholic fatty liver disease: a randomized, placebo controlled clinical trial

Authors
  • Saadati, Saeede1
  • Sadeghi, Amir2
  • Mansour, Asieh1
  • Yari, Zahra1
  • Poustchi, Hossein3
  • Hedayati, Mehdi4
  • Hatami, Behzad2
  • Hekmatdoost, Azita1
  • 1 National Nutrition and Food Technology, Research Institute, Shahid Beheshti University of Medical Sciences, Department of Clinical Nutrition and Dietetics, Faculty of Nutrition and Food Technology, Tehran, Iran , Tehran (Iran)
  • 2 Shahid Beheshti University of Medical Sciences, Gastroenterology and Liver Diseases Research Center, Research Institute for Gastroenterology and Liver Diseases, Tehran, Iran , Tehran (Iran)
  • 3 Digestive Disease Research Institute, Liver and pancreatobiliary research group, Tehran, Iran , Tehran (Iran)
  • 4 Research Institute for Endocrine Sciences, Shahid Beheshti University of Medical Sciences, Cellular and Molecular Endocrine Research Center, Tehran, Iran , Tehran (Iran)
Type
Published Article
Journal
BMC Gastroenterology
Publisher
Springer (Biomed Central Ltd.)
Publication Date
Jul 25, 2019
Volume
19
Issue
1
Identifiers
DOI: 10.1186/s12876-019-1055-4
Source
Springer Nature
Keywords
License
Green

Abstract

BackgroundThe aim of the present study was to evaluate the effects of curcumin supplementation on inflammatory indices, and hepatic features in patients with non-alcoholic fatty liver disease (NAFLD).MethodsFifty patients with NAFLD were randomized to receive lifestyle modification advice plus either 1500 mg curcumin or the same amount of placebo for 12 weeks.ResultsCurcumin supplementation was associated with significant decrease in hepatic fibrosis (p < 0.001), and nuclear factor-kappa B activity (p < 0.05) as compared with the baseline. Hepatic steatosis and serum level of liver enzymes, and tumor necrosis-α (TNF-α) significantly reduced in both groups (p < 0.05). None of the changes were significantly different between two groups.ConclusionOur results indicated that curcumin supplementation plus lifestyle modification is not superior to lifestyle modification alone in amelioration of inflammation.Trial registrationIRCT20100524004010N24, this trial was retrospectively registered on May 14, 2018.

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