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Curcumin-Induced Cell Death in Two Leukemia Cell Lines: K562 and Jurkat

Authors
Type
Published Article
Journal
Annals of the New York Academy of Sciences
Publisher
Wiley (Blackwell Publishing)
Publication Date
Dec 24, 2003
Volume
1010
Issue
1
Pages
392–392
Identifiers
DOI: 10.1196/annals.1299.071
Source
LBMCC
Keywords
License
Yellow

Abstract

Curcumin presents strong antioxidant and anticancer properties. However, molecular mechanisms leading to curcumin-induced cell death are poorly understood. The effect of curcumin was compared in two different leukemia cell lines: K562 and Jurkat. Cell death was induced in both cell lines, and apoptosis pathways were investigated by Western blot analysis. Decreases in pro-caspase 8 and 9 levels were observed. BH(3) interacting domain death agonist (Bid) was also cleaved. Jurkat cells appeared to be more sensitive to curcumin, and apoptosis takes place earlier.

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