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Cumulative Evidence for Association between IL-10 Polymorphisms and Kawasaki Disease Susceptibility: A Systematic Review and Meta-Analysis.

Authors
  • Ferdosian, Farzad1
  • Dastgheib, Seyed Alireza2
  • Morovati-Sharifabad, Majid3
  • Lookzadeh, Mohammad Hosein1, 4
  • Noorishadkam, Mahmood1, 4
  • Mirjalili, Seyed Reza1, 4
  • Akbarian-Bafghi, Mohammad Javad5
  • Neamatzadeh, Hossein4, 6
  • 1 Department of Pediatrics, Shahid Sadoughi University of Medical Sciences, Yazd, Iran. , (Iran)
  • 2 Department of Medical Genetics, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran. , (Iran)
  • 3 Department of Basic Science, Faculty of Veterinary Medicine, Ardakan University, Ardakan, Iran. , (Iran)
  • 4 Mother and Newborn Health Research Center, Shahid Sadoughi University of Medical Sciences, Yazd, Iran. , (Iran)
  • 5 Department of Healthcare Management, Bam University of Medical Sciences, Bam, Iran. , (Iran)
  • 6 Department of Medical Genetics, Shahid Sadoughi University of medical sciences, Yazd, Iran. , (Iran)
Type
Published Article
Journal
Fetal and Pediatric Pathology
Publisher
Informa UK (Taylor & Francis)
Publication Date
Apr 01, 2021
Volume
40
Issue
2
Pages
153–165
Identifiers
DOI: 10.1080/15513815.2019.1686789
PMID: 31738634
Source
Medline
Keywords
Language
English
License
Unknown

Abstract

This meta-analysis was carried out to evaluate the associations between IL-10 polymorphisms and Kawasaki disease (KD) risk. A comprehensive literature search was performed using PubMed, EMBASE, China National Knowledge Infrastructure and SciELO for all relevant studies evaluating IL-10 polymorphism and susceptibility to KD. The associations were measured by odds ratios (ORs) and its corresponding 95% confidence intervals (CIs). A total of 13 studies including four studies on -1082 A > G, four studies on -819 T > C and five studies on -592 A > C polymorphism were selected. Pooled data revealed that IL-10 -592 A > C polymorphism was significantly associated with an increased risk of KD (C vs. A: OR = 0.402, 95% CI 0.194-0.832, p = 0.014). However, IL-10 -1082 A > G and -819 T > C polymorphisms were not significantly associated with risk of KD under all five genetic models. Our results revealed that IL-10 -592 A > C polymorphism was associated with risk of KD, while IL-10 -1082 A > G and -819 T > C polymorphisms were not involved in the development of KD.

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