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A cubic B-spline-based hybrid registration of lung CT images for a dynamic airway geometric model with large deformation.

Authors
  • Yin, Youbing
  • Hoffman, Eric A
  • Ding, Kai
  • Reinhardt, Joseph M
  • Lin, Ching-Long
Type
Published Article
Journal
Physics in Medicine and Biology
Publisher
IOP Publishing
Publication Date
Jan 07, 2011
Volume
56
Issue
1
Pages
203–218
Identifiers
DOI: 10.1088/0031-9155/56/1/013
PMID: 21149947
Source
Medline
License
Unknown

Abstract

The goal of this study is to develop a matching algorithm that can handle large geometric changes in x-ray computed tomography (CT)-derived lung geometry occurring during deep breath maneuvers. These geometric relationships are further utilized to build a dynamic lung airway model for computational fluid dynamics (CFD) studies of pulmonary air flow. The proposed algorithm is based on a cubic B-spline-based hybrid registration framework that incorporates anatomic landmark information with intensity patterns. A sequence of invertible B-splines is composed in a multiresolution framework to ensure local invertibility of the large deformation transformation and a physiologically meaningful similarity measure is adopted to compensate for changes in voxel intensity due to inflation. Registrations are performed using the proposed approach to match six pairs of 3D CT human lung datasets. Results show that the proposed approach has the ability to match the intensity pattern and the anatomical landmarks, and ensure local invertibility for large deformation transformations. Statistical results also show that the proposed hybrid approach yields significantly improved results as compared with approaches using either landmarks or intensity alone.

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