The first asymmetric silylation of unsaturated lactams and amides using Cu(I)-NHC catalysts and PhMe2SiBpin has been accomplished. The method has been exploited in an expedient asymmetric synthesis of the (R)-enantiomer of the nootropic drug oxiracetam.
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The corresponding record at NLM can be accessed at https://www.ncbi.nlm.nih.gov/pubmed/24350760