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Cu(I)-NHC catalyzed asymmetric silyl transfer to unsaturated lactams and amides.

Authors
  • Pace, Vittorio
  • Rae, James P
  • Procter, David J
Type
Published Article
Journal
Organic Letters
Publisher
American Chemical Society
Publication Date
Jan 17, 2014
Volume
16
Issue
2
Pages
476–479
Identifiers
DOI: 10.1021/ol4033623
PMID: 24350760
Source
Medline
License
Unknown

Abstract

The first asymmetric silylation of unsaturated lactams and amides using Cu(I)-NHC catalysts and PhMe2SiBpin has been accomplished. The method has been exploited in an expedient asymmetric synthesis of the (R)-enantiomer of the nootropic drug oxiracetam.

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