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CT and MR imaging of neuroaxonal leukodystrophy presenting as early-onset frontal dementia.

Authors
Type
Published Article
Journal
American Journal of Neuroradiology
0195-6108
Publisher
American Society of Neuroradiology
Publication Date
Volume
27
Issue
5
Pages
1037–1039
Identifiers
PMID: 16687539
Source
Medline

Abstract

CT and MR imaging showed diffuse changes of the frontal white matter and genu of the corpus callosum with minimal atrophy and no contrast enhancement in a 41-year-old woman with progressive dementia. Brain biopsy disclosed axonal spheroids and gliosis in the white matter without macrophage or inflammatory infiltration or vessel abnormalities consistent with neuroaxonal leukodystrophy. This disease can be suspected on CT and MR imaging findings but requires neuropathologic examination to be diagnosed.

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