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Csk-homologous kinase (Chk) is an efficient inhibitor of Src-family kinases but a poor catalyst of phosphorylation of their C-terminal regulatory tyrosine.

Authors
  • Advani, Gahana1, 2, 3
  • Lim, Ya Chee1, 4
  • Catimel, Bruno5
  • Lio, Daisy Sio Seng1, 2, 3
  • Ng, Nadia L Y1, 2, 3
  • Chüeh, Anderly C5
  • Tran, Mai1, 2
  • Anasir, Mohd Ishtiaq1, 2
  • Verkade, Heather1
  • Zhu, Hong-Jian6
  • Turk, Benjamin E7
  • Smithgall, Thomas E8
  • Ang, Ching-Seng2
  • Griffin, Michael1, 2
  • Cheng, Heung-Chin9, 10, 11
  • 1 Department of Biochemistry & Molecular Biology, University of Melbourne, Parkville, VIC, 3010, Australia. , (Australia)
  • 2 Bio21 Biotechnology and Molecular Science Institute, University of Melbourne, Parkville, VIC, 3010, Australia. , (Australia)
  • 3 Cell Signalling Research Laboratories, School of Biomedical Sciences, University of Melbourne, Parkville, VIC, 3010, Australia. , (Australia)
  • 4 PAP Rashidah Sa'adatul Bolkiah Institute of Health Sciences, Universiti Brunei Darussalam, Gadong, Brunei Darussalam. , (Brunei)
  • 5 Walter and Eliza Hall Institute for Medical Research and Department of Medical Biology, University of Melbourne, Parkville, VIC, 3010, Australia. , (Australia)
  • 6 Department of Surgery, University of Melbourne, Royal Melbourne Hospital, Parkville, VIC, 3052, Australia. , (Australia)
  • 7 Department of Pharmacology, Yale University School of Medicine, New Haven, CT, USA.
  • 8 Department of Microbiology and Molecular Genetics, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.
  • 9 Department of Biochemistry & Molecular Biology, University of Melbourne, Parkville, VIC, 3010, Australia. [email protected] , (Australia)
  • 10 Bio21 Biotechnology and Molecular Science Institute, University of Melbourne, Parkville, VIC, 3010, Australia. [email protected] , (Australia)
  • 11 Cell Signalling Research Laboratories, School of Biomedical Sciences, University of Melbourne, Parkville, VIC, 3010, Australia. [email protected] , (Australia)
Type
Published Article
Journal
Cell communication and signaling : CCS
Publication Date
Aug 07, 2017
Volume
15
Issue
1
Pages
29–29
Identifiers
DOI: 10.1186/s12964-017-0186-x
PMID: 28784162
Source
Medline
Keywords
License
Unknown

Abstract

SFKs are activated by different upstream signals to adopt multiple active conformations in cells. SFKs adopting these conformations can effectively be constrained by the two complementary inhibitory mechanisms of Csk and Chk. Furthermore, the lack of this non-catalytic inhibitory mechanism accounts for SFK overactivation in the Chk-deficient colorectal cancer cells.

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