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CSF levels of carnitine in children with meningitis, neurologic disorders, acute gastroenteritis, and seizure.

Authors
  • Shinawi, M1
  • Gruener, N
  • Lerner, A
  • 1 Department of Pediatrics, Carmel Medical Center, Haifa, Israel.
Type
Published Article
Journal
Neurology
Publication Date
June 1998
Volume
50
Issue
6
Pages
1869–1871
Identifiers
PMID: 9633746
Source
Medline
License
Unknown

Abstract

Carnitine concentrations in CSF, serum, and urine in normal febrile children and children with meningitis, neurologic disorders, and dehydration were studied. Carnitine levels in CSF were 1/10 compared with serum in normal febrile children. These levels increased two- to three-fold in the pathologic conditions studied. Since damage to the blood-brain barrier occurs in these conditions, higher blood-brain barrier permeability might explain CNS carnitine accumulation.

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