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CSF CRH in abstinent cocaine-dependent patients.

Authors
  • Roy, Alec
  • Bissette, Garth
  • Williams, Redford
  • Berman, Jeffrey
  • Gonzalez, Bienvenido
Type
Published Article
Journal
Psychiatry Research
Publisher
Elsevier
Publication Date
Mar 25, 2003
Volume
117
Issue
3
Pages
277–280
Identifiers
PMID: 12686370
Source
Medline
License
Unknown

Abstract

Alterations in stress responsivity may be important in the vulnerability to become cocaine dependent. Thus, an index of hypothalamic-pituitary-adrenal (HPA) axis function was examined in abstinent cocaine-dependent patients. Cerebrospinal fluid (CSF) concentrations of corticotropin releasing factor (CRH) were determined in 29 abstinent cocaine-dependent patients and 66 normal controls. The results showed that there was no significant difference between the abstinent cocaine-dependent patients and normal controls for CSF CRH. Also, CSF CRH concentrations were not related to cocaine-craving scores in a cue-elicited cocaine-craving procedure. Thus, these data suggest that after protracted abstinence from cocaine there is no marked dysregulation of CRH systems as measured by CSF CRH concentrations.

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