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Crystal-neutrophil interactions lead to interleukin-1 synthesis.

Authors
Type
Published Article
Journal
Agents and Actions
0065-4299
Publisher
Springer-Verlag
Publication Date
Volume
34
Issue
1-2
Pages
38–41
Identifiers
PMID: 1793049
Source
Medline

Abstract

Normal human blood neutrophils were studied for their capacity to synthesize and release interleukin-1 (IL-1) species after phagocytosis of triclinic monosodium urate (MSU) and calcium pyrophosphate dihydrate crystals (CPPD). MSU crystals were more potent inducers of IL-1 generation than CPPD or unopsonized zymosan. Microcrystal-stimulated neutrophils characteristically secreted most of the newly synthesized IL-1. Colchicine partly inhibited the secretion of IL-1 by neutrophils during phagocytosis of solid particles. However, colchicine selectively inhibited IL-1 synthesis induced by microcrystals. These results suggest that neutrophil-derived IL-1 may contribute to the pathogenesis of crystal-induced arthritis.

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