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Cryoglobulinemia manifested by gangraene of almost all fingers and toes.

Authors
Type
Published Article
Journal
International angiology : a journal of the International Union of Angiology
Publication Date
Volume
29
Issue
6
Pages
560–564
Identifiers
PMID: 21173736
Source
Medline
License
Unknown

Abstract

Cryoglobulinemia is a rather rare condition accompanying quite a broad spectrum of different states and diseases. Mixed or polyclonal cryoglobulins can be seen in patients with autoimmune disorders, chronic infections and lymphoproliferative disorders. Monoclonal cryoglobulins are often revealed in patients with multiple myeloma or Waldenström's macroglobulinemia. Cryoglobulinemia is in most cases asymptomatic. Cryoglobulinemic vasculitis is an immune complex-mediated systemic disorder involving mostly small, but sometimes also larger vessels. In this report, we describe a case of a patient presented with gangrene of almost all fingers and toes, who was finally diagnosed and treated as cryoglobulinemic vasculitis due to multiple myeloma.

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