Cryo-EM structure of transcription termination factor Rho from Mycobacterium tuberculosis reveals bicyclomycin resistance mechanism
- Authors
- Type
- Published Article
- Journal
- Communications Biology
- Publisher
- Nature Publishing Group UK
- Publication Date
- Feb 09, 2022
- Volume
- 5
- Issue
- 1
- Identifiers
- DOI: 10.1038/s42003-022-03069-6
- Source
- Springer Nature
- Disciplines
- License
- Green
Abstract
Cryo-EM shows that M. tuberculosis Rho-factor adopts an open, ring-shaped hexamer conformation and a steric bulk in the cavity for bicyclomycin binding, which explains resistance to the antibiotic.