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CRTH2 mediates the activation of human Th2 cells in response to PGD(2) released from IgE/anti-IgE treated nasal polyp tissue.

Authors
  • 1
  • 1 Upper Airways Research Laboratory, Department of Otorhinolaryngology, Ghent University Hospital, Ghent, Belgium. , (Belgium)
Type
Published Article
Journal
Allergy
1398-9995
Publication Date
Volume
65
Issue
3
Pages
304–310
Identifiers
DOI: 10.1111/j.1398-9995.2009.02204.x
PMID: 19839971
Source
Medline
License
Unknown

Abstract

These data suggest that in immunologically activated nasal polyp tissue, PGD(2) produced by mast cells promotes the migration of Th2 cells through a CRTH2 dependent mechanism.

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