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The crosstalk between m6A RNA methylation and other epigenetic regulators: a novel perspective in epigenetic remodeling.

Authors
  • Zhao, Yanchun1
  • Chen, Yunhao2
  • Jin, Mei1
  • Wang, Jin1
  • 1 Department of Pathology, Sir Run Run Shaw Hospital, School of Medicine, Zhejiang University, Hangzhou, 310000, China. , (China)
  • 2 Division of Hepatobiliary and Pancreatic Surgery, Department of Surgery, the First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, 310000, China. , (China)
Type
Published Article
Journal
Theranostics
Publisher
Ivyspring International Publisher
Publication Date
Jan 01, 2021
Volume
11
Issue
9
Pages
4549–4566
Identifiers
DOI: 10.7150/thno.54967
PMID: 33754077
Source
Medline
Keywords
Language
English
License
Unknown

Abstract

Epigenetic regulation involves a range of sophisticated processes which contribute to heritable alterations in gene expression without altering DNA sequence. Regulatory events predominantly include DNA methylation, chromatin remodeling, histone modifications, non-coding RNAs (ncRNAs), and RNA modification. As the most prevalent RNA modification in eukaryotic cells, N6-methyladenosine (m6A) RNA methylation actively participates in the modulation of RNA metabolism. Notably, accumulating evidence has revealed complicated interrelations occurring between m6A and other well-known epigenetic modifications. Their crosstalk conspicuously triggers epigenetic remodeling, further yielding profound impacts on a variety of physiological and pathological processes, especially tumorigenesis. Herein, we provide an up-to-date review of this emerging hot area of biological research, summarizing the interplay between m6A RNA methylation and other epigenetic regulators, and highlighting their underlying functions in epigenetic reprogramming. © The author(s).

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