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Crosstalk Between Lipids and Mitochondria in Diabetic Kidney Disease

Authors
  • Ducasa, G. Michelle1, 2
  • Mitrofanova, Alla1, 2, 2
  • Fornoni, Alessia1, 2
  • 1 University of Miami, Miller School of Medicine, 1580 NW 10th Avenue, Miami, FL, USA , Miami (United States)
  • 2 University of Miami, Miller School of Medicine, Miami, FL, USA , Miami (United States)
Type
Published Article
Journal
Current Diabetes Reports
Publisher
Springer-Verlag
Publication Date
Nov 21, 2019
Volume
19
Issue
12
Identifiers
DOI: 10.1007/s11892-019-1263-x
Source
Springer Nature
Keywords
License
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Abstract

Purpose of ReviewThe goal of this review is to review the role that renal parenchymal lipid accumulation plays in contributing to diabetic kidney disease (DKD), specifically contributing to the mitochondrial dysfunction observed in glomerular renal cells in the context of DKD development and progression.Recent FindingsMitochondrial dysfunction has been observed in experimental and clinical DKD. Recently, Ayanga et al. demonstrate that podocyte-specific deletion of a protein involved in mitochondrial dynamics protects from DKD progression. Furthermore, our group has recently shown that ATP-binding cassette A1 (a protein involved in cholesterol and phospholipid efflux) is significantly reduced in clinical and experimental DKD and that genetic or pharmacological induction of ABCA1 is sufficient to protect from DKD. ABCA1 deficiency in podocytes leads to mitochondrial dysfunction observed with alterations of mitochondrial lipids, in particular, cardiolipin (a mitochondrial-specific phospholipid). However, through pharmacological reduction of cardiolipin peroxidation DKD progression is reverted.SummaryLipid metabolism is significantly altered in the diabetic kidney and renders cellular components, such as the podocyte, susceptible to injury leading to worsened DKD progression. Dysfunction of the lipid metabolism pathway can also lead to mitochondrial dysfunction and mitochondrial lipid alteration. Future research aimed at targeting mitochondrial lipids content and function could prove to be beneficial for the treatment of DKD.

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