Affordable Access

deepdyve-link
Publisher Website

Crosstalk Between Innate and T Cell Adaptive Immunity With(in) the Muscle

Authors
  • Bonomo, Adriana C.1, 2, 3
  • Pinto-Mariz, Fernanda4
  • Riederer, Ingo1, 2, 3, 5
  • Benjamim, Claudia F.3, 6
  • Butler-Browne, Gillian7
  • Mouly, Vincent7
  • Savino, Wilson1, 2, 3
  • 1 Laboratory on Thymus Research, Oswaldo Cruz Institute, Oswaldo Cruz Foundation, Rio de Janeiro , (Brazil)
  • 2 National Institute of Science and Technology on Neuroimmunomodulation (INCT-NIM), Oswaldo Cruz Institute, Oswaldo Cruz Foundation, Rio de Janeiro , (Brazil)
  • 3 Rio de Janeiro Research Network on Neuroinflammation (RENEURIN), Oswaldo Cruz Institute, Oswaldo Cruz Foundation, Rio de Janeiro , (Brazil)
  • 4 Marzagão Gesteira Institute of Pediatrics, Federal University of Rio de Janeiro, Rio de Janeiro , (Brazil)
  • 5 School of Pharmacy and Biomedical Sciences, University of Central Lancashire, Preston , (United Kingdom)
  • 6 Program of Immunobiology, Institute of Biophysics Carlos Chagas Filho, Federal University of Rio de Janeiro, Rio de Janeiro , (Brazil)
  • 7 Sorbonne Université, Inserm, Institut de Myologie, U974, Center for Research in Myology, Paris , (France)
Type
Published Article
Journal
Frontiers in Physiology
Publisher
Frontiers Media SA
Publication Date
Sep 18, 2020
Volume
11
Identifiers
DOI: 10.3389/fphys.2020.573347
PMID: 33071827
PMCID: PMC7531250
Source
PubMed Central
Keywords
License
Unknown

Abstract

Growing evidence demonstrates a continuous interaction between the immune system and the skeletal muscle in inflammatory diseases of different pathogenetic origins, in dystrophic conditions such as Duchenne Muscular Dystrophy as well as during normal muscle regeneration. Although one component of the innate immunity, the macrophage, has been extensively studied both in disease conditions and during cell or gene therapy strategies aiming at restoring muscular functions, much less is known about dendritic cells and their primary immunological targets, the T lymphocytes. This review will focus on the dendritic cells and T lymphocytes (including effector and regulatory T-cells), emphasizing the potential cross talk between these cell types and their influence on the structure and function of skeletal muscle.

Report this publication

Statistics

Seen <100 times