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Cross-phenotype analysis of Immunochip data identifies KDM4C as a relevant locus for the development of systemic vasculitis.

Authors
  • Ortiz-Fernández, Lourdes1
  • Carmona, Francisco David2
  • López-Mejías, Raquel3
  • González-Escribano, Maria Francisca4
  • Lyons, Paul A5
  • Morgan, Ann W6
  • Sawalha, Amr H7
  • Smith, Kenneth G C5
  • González-Gay, Miguel A3, 8
  • Martín, Javier1
  • 1 Instituto de Parasitologia y Biomedicina Lopez-Neyra, Granada, Spain. , (Spain)
  • 2 Departamento de Genética e Instituto de Biotecnología, Universidad de Granada, Granada, Spain. , (Spain)
  • 3 Epidemiology, Genetics and Atherosclerosis Research Group on Systemic Inflammatory Diseases, Rheumatology Division, Hospital Universitario Marqués de Valdecilla, IDIVAL, Santander, Spain. , (Spain)
  • 4 Department of Immunology, Hospital Universitario Virgen del Rocío (IBiS,CSIC, US), Sevilla, Spain. , (Spain)
  • 5 Department of Medicine, University of Cambridge School of Clinical Medicine, Cambridge Biomedical Campus, Cambridge, UK.
  • 6 Leeds Institute of Rheumatic and Musculoskeletal Medicine, University of Leeds, and NIHR Leeds Biomedical Research Centre, Leeds Teaching Hospitals NHS Trust, Leeds, UK.
  • 7 Division of Rheumatology, Department of Internal Medicine, University of Michigan, Ann Arbor, Michigan, USA.
  • 8 School of Medicine, University of Cantabria, Santander, Spain. , (Spain)
Type
Published Article
Journal
Annals of the Rheumatic Diseases
Publisher
BMJ
Publication Date
Jan 27, 2018
Identifiers
DOI: 10.1136/annrheumdis-2017-212372
PMID: 29374629
Source
Medline
Keywords
License
Unknown

Abstract

Through a combined analysis of Immunochip data, we have identified KDM4C as a new risk gene shared between systemic vasculitides, consistent with the increasing evidences of the crucial role that the epigenetic mechanisms have in the development of complex immune-mediated conditions.

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