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Crosscurrents in HIV-1 evolution

Authors
  • Blankson, Joel N1
  • Bailey, Justin R1
  • Siliciano, Robert F1
  • 1 Johns Hopkins University School of Medicine, Baltimore, Maryland, 21205, USA , Baltimore (United States)
Type
Published Article
Journal
Nature Immunology
Publisher
Springer Nature
Publication Date
Feb 01, 2006
Volume
7
Issue
2
Pages
121–122
Identifiers
DOI: 10.1038/ni0206-121
Source
Springer Nature
License
Yellow

Abstract

Substitutions in CD8+ T cell epitopes in viral proteins can alter the complex interaction between viruses and host immunity. Reduced viral fitness and recognition of altered and subdominant epitopes are possible outcomes.

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