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Cross-talk between receptors coupled to calcium currents in adult but not neonatal rat sensory neurons.

Authors
  • Wanke, E
  • Becchetti, A
  • Bertollini, L
  • Ferroni, A
Type
Published Article
Journal
Cell biology international reports
Publication Date
Dec 01, 1989
Volume
13
Issue
12
Pages
1165–1175
Identifiers
PMID: 2561467
Source
Medline
License
Unknown

Abstract

In adult rat sensory neurons Ca2+ currents were studied with the whole-cell patch-clamp technique. Two categories of neuromodulators, known to activate different 2nd messenger systems: 1) angiotensin II (AII), bovine serum albumin (BSA), Acetylcholine (ACh) and 2) GABA, stimulated the low-voltage activated (LVA) and inhibited the high voltage activated (HVA) currents, respectively. The simultaneous application of the two types of drugs failed to inhibit the HVA current via a putative cross-talk between the two 2nd messengers.

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