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Cross-reactivity of vector-borne metacyclic forms of Trypanosoma cruzi with mammalian and culture stages.

Authors
  • Villalta, F
  • Kierszenbaum, F
Type
Published Article
Journal
The Journal of protozoology
Publication Date
May 01, 1983
Volume
30
Issue
2
Pages
329–331
Identifiers
PMID: 6195335
Source
Medline
License
Unknown

Abstract

Metacyclic forms of Trypanosoma cruzi isolated from the hindgut of infected insect vectors (Rhodnius prolixus) were found to be immunologically cross-reactive with cultured epimastigote, amastigote, and metacyclic stages of the parasite as well as with bloodstream trypomastigote forms by direct agglutination and indirect immunofluorescence techniques. Sera specific for each of these forms of the parasite systematically yielded maximal antibody titers when measured against the homologous antigen, indicating that antigenic determinants are shared by all of the developmental forms used in this work. Supporting this conclusion were the significant reductions in anti-insect-derived metacyclic antibody titer caused by absorption with any of the other life stages of T. cruzi. These results are relevant to the potential use of laboratory-grown forms of T. cruzi in vaccination against a natural infection with this parasite.

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