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Cross-excitation in dorsal root ganglia does not depend on close cell-to-cell apposition.

Authors
  • Shinder, V
  • Amir, R
  • Devor, M
Type
Published Article
Journal
Neuroreport
Publisher
Ovid Technologies (Wolters Kluwer) - Lippincott Williams & Wilkins
Publication Date
Dec 21, 1998
Volume
9
Issue
18
Pages
3997–4000
Identifiers
PMID: 9926836
Source
Medline
License
Unknown

Abstract

About 90% of neurons in dorsal root ganglia (DRGs) of rats 2-5 weeks of age are depolarized and excited by impulse activity in neighboring neurons that share the same DRG. Synaptic contacts are extremely rare in DRGs, but instances of close membrane apposition between pairs of neuronal somata are not uncommon, especially in prenatal rats. Close membrane apposition could permit electrotonic interactions among neighboring DRG neurons. We carried out an ultrastructural examination of DRGs taken from rats 2-5 weeks of age and found that by this age < 2% of cells remain in close apposition with neighbors. The remainder are separated by one or two layers of satellite glial cytoplasm. It is, therefore, unlikely that close apposition between adjacent neurons contributes significantly to functional cross-excitation in the DRG.

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