The results of treatment of 28 patients with "appendicitis-like" form of the Crohn's disease are summarized. Diagnosis before the operation was supposed in 6 patients. Operated on were 25 patients. All of them underwent appendectomy. Differential diagnosis of acute appendicitis and Crohn's disease in difficult, of main importance are the data of clinical investigation. In diagnosis verification by the data of histologic conclusion, the performance of postoperative specific antiinflammatory therapy is mandatory. Danger of appendectomy under such conditions is exaggerated. The result of treatment at the period of from 3 to 20 years was studied in 22 patients operated on. Performance of postoperative treatment contributed to abatement of the disease, achievement of a satisfactory long-term result in all the patients.