Apple peel is considered as a waste product in many fruit industries but it is a significant source of various phytochemicals, majorly polyphenols. Polyphenolic compounds are included among the phytochemicals and possess great antioxidant potential. These are the valuable natural compounds possessing a range of biological and chemical properties. Apple peel contains anti-oxidative, anti-proliferative, anti-carcinogenic properties and also have anti-inflammatory properties. Polyphenols are also of great value as they possess free radical scavenging activities. Major phenolics available in apple peel are epicatechin, oligomer, trimer, glycosides quercetin, chlorogenic acid, phloridzin3-hydroxy and procyanidin etc. Polyphenolics are extracted by using different techniques and methods like ultrasound assisted extraction and microwave extraction etc. They also perform a versatile role in disease management like cancer, cardiovascular diseases, diabetes, inflammatory bowel disease, arthritis and many others.