Affordable Access

deepdyve-link
Publisher Website

The Role of Nuclear Factor Kappa B (NF-κB) in Development and Treatment of COVID-19: Review.

Authors
  • Gudowska-Sawczuk, Monika1
  • Mroczko, Barbara1, 2
  • 1 Department of Biochemical Diagnostics, Medical University of Bialystok, 15-269 Bialystok, Poland. , (Poland)
  • 2 Department of Neurodegeneration Diagnostics, Medical University of Bialystok, 15-269 Bialystok, Poland. , (Poland)
Type
Published Article
Journal
International Journal of Molecular Sciences
Publisher
MDPI AG
Publication Date
May 09, 2022
Volume
23
Issue
9
Identifiers
DOI: 10.3390/ijms23095283
PMID: 35563673
Source
Medline
Keywords
Language
English
License
Unknown

Abstract

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) causes Coronavirus Disease 19 (COVID-19), a disease that has affected more than 500 million people worldwide since the end of 2019. Due to its high complications and death rates, there is still a need to find the best therapy for SARS-CoV-2 infection. The dysregulation of the inflammatory response in COVID-19 plays a very important role in disease progression. It has been observed that abnormal activity of Nuclear Factor kappa B (NF-κB) is directly associated with, inter alia, increased synthesis of proinflammatory factors. Therefore, this review paper focuses on the functions of NF-κB in the development of SARS-CoV-2 infection and potential application of NF-κB inhibitors in COVID-19 immunotherapy. A comprehensive literature search was performed using the MEDLINE/PubMed database. In the current review, it is highlighted that NF-κB plays important functions in the modulation of an adaptive inflammatory response, including inducing the expression of proinflammatory genes. Increased activation of NF-κB in SARS-CoV-2 infection was observed. The association between NF-κB activation and the expression of SARS-CoV-2 structural and non-structural proteins were also reported. It was observed that modulation of NF-κB using, e.g., traditional Chinese medicine or glucocorticosteroids resulted in decreased synthesis of proinflammatory factors caused by SARS-CoV-2 infection. This review summarizes the role of NF-κB in COVID-19 and describes its potential immunotherapeutic target in treatment of SARS-CoV-2 infection. However, indisputably more studies involving patients with a severe course of COVID-19 are sorely needed.

Report this publication

Statistics

Seen <100 times