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CREB: the unindicted cancer co-conspirator.

Authors
  • Conkright, Michael D1
  • Montminy, Marc
  • 1 The Salk Institute for Biological Studies, 10010 N. Torrey Pines Rd, La Jolla, California 92037, USA.
Type
Published Article
Journal
Trends in Cell Biology
Publisher
Elsevier
Publication Date
Sep 01, 2005
Volume
15
Issue
9
Pages
457–459
Identifiers
PMID: 16084096
Source
Medline
License
Unknown

Abstract

The transcription factor cAMP response-element binding protein (CREB) participates in a diverse array of cellular processes, including survival, proliferation and glucose metabolism. A new report by Shankar et al. shows that patients with acute myeloid leukemia (AML) have a greater incidence of relapse when intracellular levels of CREB are elevated. By enhancing expression of certain cell-cycle genes, CREB appears to promote growth-factor-independent proliferation and survival of myeloid cells. The results provide new insights into CREB function and suggest potential avenues for therapeutic intervention.

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