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CREB: the unindicted cancer co-conspirator.

Authors
Type
Published Article
Journal
Trends in Cell Biology
0962-8924
Publisher
Elsevier
Publication Date
Volume
15
Issue
9
Pages
457–459
Identifiers
PMID: 16084096
Source
Medline

Abstract

The transcription factor cAMP response-element binding protein (CREB) participates in a diverse array of cellular processes, including survival, proliferation and glucose metabolism. A new report by Shankar et al. shows that patients with acute myeloid leukemia (AML) have a greater incidence of relapse when intracellular levels of CREB are elevated. By enhancing expression of certain cell-cycle genes, CREB appears to promote growth-factor-independent proliferation and survival of myeloid cells. The results provide new insights into CREB function and suggest potential avenues for therapeutic intervention.

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