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A CREB-Sirt1-Hes1 Circuitry Mediates Neural Stem Cell Response to Glucose Availability

Authors
  • Salvatore Fusco
  • Lucia Leone
  • Saviana Antonella Barbati
  • Daniela Samengo
  • Roberto Piacentini
  • Giuseppe Maulucci
  • Gabriele Toietta
  • Matteo Spinelli
  • Michael McBurney
  • Giovambattista Pani
  • Claudio Grassi
Type
Published Article
Journal
Cell Reports
Publisher
Elsevier
Publication Date
Jan 27, 2016
Identifiers
DOI: 10.1016/j.celrep.2015.12.092
PMID: 26804914
Source
MyScienceWork
Keywords
License
Unknown

Abstract

Graphical Abstract Highlights d Low glucose promotes NSC proliferation and self-renewal in vitro d Glucose regulates Hes-1 expression through a CREB-Sirt1 metabolic switch d Calorie restriction triggers the CREB-Sirt1-Hes1 switch in the hippocampus of mice d This circuitry may link nutrient excess with neurodegeneration and brain aging In Brief Using a combination of in vitro and in vivo studies, Fusco et al. find that excess glucose impairs the self-renewal capacity of neural stem cells through a molecular circuit that involves the transcription factor CREB and Sirtuin 1. The authors suggest that this circuitry may link nutrient excess with neurodegeneration and brain aging.

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