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Creatine synthesis and transport during rat embryogenesis: spatiotemporal expression of AGAT, GAMT and CT1.

Authors
  • Braissant, Olivier
  • Henry, Hugues
  • Villard, Anne-Marie
  • Speer, Oliver
  • Wallimann, Theo
  • Bachmann, Claude
Type
Published Article
Journal
BMC Developmental Biology
Publisher
Springer (Biomed Central Ltd.)
Publication Date
Jan 01, 2005
Volume
5
Pages
9–9
Identifiers
PMID: 15918910
Source
Medline
License
Unknown

Abstract

Our results suggest that de novo synthesis of Cr by AGAT and GAMT, as well as cellular Cr uptake by CT1, are essential during embryonic development. This work provides new clues on how creatine can be provided to developing tissues, and suggests that Cr deficiencies might induce irreversible damages already in utero, particularly on the nervous system.

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