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[Cranial irradiation induces premature activation of the gonadotropin-releasing-hormone].

Authors
Type
Published Article
Journal
Klinische Pädiatrie
Publication Date
Volume
213
Issue
4
Pages
239–243
Identifiers
PMID: 11528557
Source
Medline

Abstract

The GnRH-pulse generator is very radiosensitive as low dose irradiation causes precocious puberty, whereas high dose irradiation is associated with delayed sexual maturation. Radiation induced precocious puberty might be caused by damage to inhibitory GABAergic neurons leading to desinhibition and premature activation of GnRH neurons. Our animal model of cranial irradiation seems to be suitable to study neurotransmitter disorders, molecular mechanisms and potential preventive intervention of radiation induced pubertal changes.

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