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CRAC inhibitors: identification and potential.

Authors
  • Derler, Isabella
  • Fritsch, Reinhard
  • Schindl, Rainer
  • Romanin, Christoph
Type
Published Article
Journal
Expert opinion on drug discovery
Publication Date
Jul 01, 2008
Volume
3
Issue
7
Pages
787–800
Identifiers
DOI: 10.1517/17460441.3.7.787
PMID: 23496221
Source
Medline
License
Unknown

Abstract

For drug development, fluorescence microscopy adaptable for high-throughput screening will provide a powerful assay to mechanistically identify potential CRAC inhibitors that act on various stages within the STIM1/ORAI1 activation pathway visualized by fluorescent-tagged proteins.

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