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[Cp*RhCl2]2-catalyzed ortho-C-H bond amination of acetophenone o-methyloximes with primary N-chloroalkylamines: convenient synthesis of N-alkyl-2-acylanilines.

Authors
  • Ng, Ka-Ho
  • Zhou, Zhongyuan
  • Yu, Wing-Yiu
Type
Published Article
Journal
Chemical Communications
Publisher
The Royal Society of Chemistry
Publication Date
Aug 14, 2013
Volume
49
Issue
63
Pages
7031–7033
Identifiers
DOI: 10.1039/c3cc42937g
PMID: 23765053
Source
Medline
License
Unknown

Abstract

Rh(III)-catalyzed aromatic C-H amination of acetophenone o-methyloximes with primary N-chloroalkylamines was developed, and the arylamine products were obtained in up to 92% yield. The reaction probably involves rate-limiting electrophilic C-H bond cleavage (kH/kD = 2).

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