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Coxsackievirus B3 persistence and myocarditis in N:NIH(S) II nu/nu and +/nu mice.

Authors
  • Schnurr, D P
  • Cao, Y
  • Schmidt, N J
Type
Published Article
Journal
The Journal of general virology
Publication Date
Jul 01, 1984
Volume
65 ( Pt 7)
Pages
1197–1201
Identifiers
PMID: 6747601
Source
Medline
License
Unknown

Abstract

N:NIH(S) II nu/nu (athymic) and +/nu (euthymic) mice were inoculated with coxsackievirus B3 (CBV-3) and examined at various times after infection for virus titres in the heart, myocarditis and serum neutralizing antibodies. Virus was recovered from the hearts of nu/nu mice for up to 94 days post-inoculation, but was not recovered from the hearts of any +/nu mice beyond 14 days. Inflammatory cell infiltration and necrosis were present in the hearts of +/nu mice at all harvest times (7, 14, 21 and 28 days). Inflammation and necrosis did not become evident in nu/nu mice until 14 days post-inoculation, and was the present in mice from each harvest until the end of the experiment (94 days). In athymic mice, myocarditis showed a strong correlation with persistence of CBV-3 in the heart. In N:NIH(S) II mice, the presence (+/nu) or absence (nu/nu) of a thymus had a major influence on the clearance of virus from the heart and on the development of myocarditis.

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